Searchable abstracts of presentations at key conferences in endocrinology

ea0029p806 | Endocrine tumours and neoplasia | ICEECE2012

Stem cell genes are deregulated in parathyroid tumours

Vaira V. , Verdelli C. , Forno I. , Elli F. , Guarnieri V. , Ferrero S. , Scillitani A. , Costa E. , Vicentini L. , Steffano G. , Cetani F. , Spada A. , Bosari S. , Corbetta S.

In our previous investigation on microRNAs expression pattern in parathyroid carcinomas (Ca), we detected the over-expression of microRNAs belonging to C19MC, the largest human cluster on chromosome 19q13.41. In the present study, the analysis of the expression of selected C19MC and the closely distal MIR371-3 clusters microRNAs (MIR512-3p, MIR517C, MIR520H and MIR372) was extended to 11 Ca, 24 adenomas (Ad) and 6 normal glands. The four microRNAs was expressed in 11% of parat...